Researchers from the University of Granada, Hospital La Paz-Carlos III of Madrid and the Health Science Center the University of Texas (united States) have discovered that the intake of melatonin, a natural hormone, helps you burn calories and stop fat.
The team of researchers from the three centers has discovered a new molecular mechanism of the effects anti-obesity that has the chronic administration of melatonin, a natural hormone that the body secretes during the night.
To develop the study, whose results have been published on the magazine Journal of Pineal Research, we administered melatonin recurrent and chronic to a group of obese rats with diabetes.
“The results have been surprising, since the animals that were treated with melatonin saw not only increased the mass of brown adipose tissue, but also improved the thermogenic activity of your body and, in parallel, decreased the mass of white adipose tissue dangerous, the central or visceral”, explains in a press release, the lead author of the work, the professor of Pharmacology Ahmad Agile Abdalla, the Center for Biomedical Research of the University of Granada.
Obesity, with a high impact on health, is the present responsible of up to 3 million deaths per year and the number of obese people in Spain grows in a gradual manner to affect around 27 % of the population.
Researchers have shown that melatonin is closely linked with the loss of body weight gain, as at the tissue level, it increases the amount of brown fat; and at the level of organs, increases the mass and functionality of mitochondrial among others.
Previous studies of several international groups, including the University of Granada, had already shown that melatonin has powerful antioxidant effects, anti-inflammatory and anti-obesogenic.
The effect for obesity is performed by two mechanisms thermogenics since melatonin has the ability to convert white fat, subcutaneous fat, beige, and increase the amount of this brown fat and the thermogenic activity.
“We have shown that melatonin has the function to regulate obesity in rodents, and in animals, but that itself, without affecting the food intake and does not affect the physical activity, hence we thought that it could be one more tool to fight against obesity,” said the researcher.
The research work led by Ahmad Agile has joined in collaboration with Gumersindo Fernández-Vázquez, specialist in endocrinology and nutrition in the service of Endocrinology and Nutrition, Hospital La Paz-Carlos III of Madrid, and Russel Reiter of the Department of Cellular and Structural Biology, Health Science Center the University of Texas.